Alpha-Mannosidase, Blood (Referred Out) - Saskatoon
Discipline
Biochemistry
Overview
Description
Test ordering requirements
Forms required
- Requisitions must have specific test indicated
- Miscellaneous Specimen Requisition Form #101878 or SHR Laboratory Medicine Community Laboratory Requisition Form #101064 or Acute Care Phlebotomy Requisition Form #101062
Alias
- Mannosidosis
Specimen Information
Specimen types accepted
- Whole blood
Specimen collection container
- Preferred collection container: Dark Green (Lithium Heparin) 4.0 mL
- Alternate collection container: Dark Green (Sodium Heparin) 4.0 mL
Required volume
- Optimal volume: 4 mL whole blood
- Minimum/pediatric volume: 1 mL whole blood
Transport and stability
- Whole blood must be received within 24 hours of collection
- Store whole blood at room temperature
- Neonatal Screen Card should be spotted with whole blood within 24 hours of collection
- Once spotted, the Neonatal Screen Card should be allowed to dry for 3-4 hours and shipped to referral laboratory at ambient temperature.
Rejection criteria
- Specimens received where the proper collection protocols were not followed
- LSM-933 Pathology and Laboratory Medicine Acceptance and Rejection Criteria
Testing Information
Relevant clinical history
- Family history
- Must include diagnosis and/or patient symptoms on the requisition
Clinical interpretation
- Result interpretation should be correlated with clinical and other laboratory findings
Performance
Methodology
- Liquid chromatography - tandem mass spectrometry
Days/times performed
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Maximum laboratory time
Results reporting
- 2 week turnaround time by referral laboratory
Other information
Additional comments
- To evaluate alpha-mannosidosis; a lysosomal storage disorder
- Requests for testing should be supported by a high index of suspicion specific to the disorder, and/or by the results of an abnormal urine oligosaccharides screen and evidence from other relevant testing
- The Neonatal Screen Card will be spotted when whole blood received in the lab. Alpha-mannosidase enzyme activity is determined using dried blood spots
Last Updated: February 12, 2026